This instrument will enable the study of the interaction between the extremely intense LCLS X-ray pulses and the basic constituents of matter: atoms and molecules.

This instrument will take advantage of the extremely bright, ultrashort LCLS pulses of hard X-rays to allow imaging of non-periodic nanoscale objects, including single or small clusters of biomolecules at or near atomic resolution.

This instrument observes matter at temperatures exceeding 10,000 Kelvin and at pressures 10 million times the earth's atmospheric pressure at sea-level, enabling unprecedented understanding of exotic states of matter.

This instrument will primarily make use of the ability for short pulses of X-rays to limit damage to samples during the exposure. This will allow for example the study of metal-containing macromolecules which are particularly sensitive to radiation damage due to the high absorption of X-rays by the metal atoms.

This instrument will enable the high brightness and timing capability of the LCLS to be applied to scattering and imaging experiments that require the use of soft X-rays.

This instrument will observe dynamical changes of large groups of atoms in condensed matter systems over a wide range of time scales.

This instrument will predominantly use a fast optical laser to generate transient states of matter, and the hard X-ray pulse from the LCLS to probe the structural dynamics initiated by the laser excitation.

The LCLS-2 Strategic Initiative (L2SI) Instruments are projects that will develop new instrumentation to leverage the high repetition rate LCLS-II FEL source. The envisioned instruments will address the LCLS-II Scientific Opportunities and be installed in the LCLS Near Experimental Hall (NEH). Two of the four instruments (NEH 1.1 and TXI) will occupy the space that is currently home to the AMO and SXR instruments. The two monochromatic instruments will be located on the ground level of the NEH, adjacent to the pump laser laboratory.