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An Office of Science User Facility

LCLS Standard Configurations for Run 16

 

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AMO Standard Configuration for Run 16

With this new standard configuration, AMO will be able to support various time-resolved X-ray and/or IR pump X-ray probe experiments examining the ultrafast molecular dynamics in gas phase.

 
To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal.  Please see the table of required parameters. To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal.

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CXI Standard Configuration for Run 16

Liquid Jets with the CXI 1 micron Focus

CXI will be configured to use the 1 micron KB focus inside the 1 micron sample chamber. The liquid jet mechanical system will be available and any sample delivery system compatible with this mechanical system using the standard nozzle rods will be supported. This includes Gas Dynamic Virtual Nozzle (GDVN), Lipidic Cubic Phase (LCP), the Microfluidic Electrokinetic Sample Holder (MESH), or other viscous extrusion systems, many types of mixing nozzles and any other system that can be mounted on the nozzle rod. The CXI sample chamber will be equipped with an on-axis jet viewing system as well as a perpendicular high resolution jet imaging system. A post-sample attenuator mount can be available if needed. Also supported will be time-resolved experiments employing either: a nanosecond optical parametric oscillator (410-2200 nm); the fundamental (800 nm) or second harmonic (400 nm) of the CXI ~50-150fs Ti:Sapphire laser; or a wavelength accessible by the CXI femtosecond optical parametric amplifier (480-2400 nm). The pump laser beam will be delivered collinear to the x-ray beam with in-coupling ~250 mm upstream of the sample with a focal length of ~300mm. The CXI time tool will be available for fs laser experiments. Users should expect that only one of the multiple laser options can be supported for a given experiment.

With this standard configuration, CXI will be able to support Serial Femtosecond Crystallography (SFX) experiments with or without a pump laser and Small Angle and Wide Angle X-ray Scattering (SAXS/WAXS) with or without a pump laser using a wide variety of sample delivery methods, either LCLS-owned or supplied by the user groups. Two full size CSPADs can be available, one for high angle close to the sample with a second detector downstream if absolutely necessary. The second CSPAD will typically be used for Protein Crystal Screening (PCS) by another group parasitically using the beam passing through the whole in the front detector. Users of the standard configuration at CXI should expect PCS beamtime running at the same time and their beamtime.

 

See the detailed description of the CXI Standard Configuration.

To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. Please see the  table of required parameters. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the instrument staff.

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MEC Standard Configuration for Run 16

X-Ray Diffraction or Thomson Scattering on Shocked Material

Two variations of the standard configuration are available: the X-ray diffraction variation (XRD) and Thomson scattering variation (XRTS). User supplied detector cannot be fielded in either standard configuration. User may request all standard MEC beamline devices and diagnostics, and the request needs to be explicitly mentioned in the proposal.

 
To be considered for scheduling in either standard configuration, users will be required to add a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. Please see the  table of required parameters. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so Users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the MEC instrument staff.

 

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MFX Standard Configuration for Run 16

#1 Goniometer system with sample mounting robot

The Macromolecular Femtosecond Crystallography (MFX) instrument will be configured to perform crystallography experiments using fixed-target samples. A goniometer system developed by the Structural Molecular Biology (SMB) team at SSRL will be deployed in the MFX hutch for this purpose. The system consists of a goniometer with scanning and rotation capabilities to precisely orient and scan crystals, and an on-axis, (visible and NIR light compatible), sample microscope. The crystals can be mounted on grids, chips, loops, meshes or any standard mounting system already supported by the SMB group. The incident photon energy is preferred to be 9.5 keV but justified deviations can be considered. The x-ray focus can vary over a range of ~2-3 µm to ~100 µm. Measurements at cryo-cooled temperatures or room temperature will be possible. The setup includes the option of an on-axis cryo-cooler to maintain crystals at temperatures of 278 to 100K during the measurements or an Arinax humidity control instrument may be requested for controlled humidity (30.0 % to 99.8 % RH) during measurements at ambient temperatures. A sample exchange robot, the Stanford Automated Mounting (SAM) system, may be used to exchange samples on compatible magnetic bases held in SSRL cassettes or uni-pucks from inside a liquid nitrogen filled storage Dewar. Samples at ambient temperatures may be mounted from 10 sample base storage locations on the side of the SAM robot. The detector is a Rayonix 325MX that operates at 1 Hz. The control of data collection will be performed using Blu-Ice/DCSS. No pump laser will be provided.

More detailed information on what is supported by the standard SMB suite of capabilities for sample mounting, data collection modes, etc. can be found at smb.slac.stanford.edu .

Use of this Standard Configuration is contingent on acceptance by the users to use the following acknowledgment in any presentation or publication: "The SSRL Structural Molecular Biology Program is supported by the DOE Office of Biological and Environmental Research, and by the National Institutes of Health, National Institute of General Medical Sciences (including P41GM103393). The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of NIGMS or NIH."

See the detailed description of the MFX Standard Configuration #1.

To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. Please see the  table of required parameters of the MFX Standards Configuration #1. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the LCLS instrument staff or the SMB support staff.

#2 Helium-Rich Ambient (HERA) instrument for time-resolved liquid jet crystallography

The Macromolecular Femtosecond Crystallography (MFX) instrument will be configured to perform crystallography experiments with liquid jets inside a helium filled enclosure. A liquid jet mechanical system will be available to move the jet and any sample delivery system compatible with this mechanical system using the standard nozzle mount will be supported. This includes Gas Dynamic Virtual Nozzle (GDVN), Lipidic Cubic Phase (LCP), the Microfluidic Electrokinetic Sample Holder (MESH), or other viscous extrusion systems, many types of mixing nozzles and any other system that can be mounted on the nozzle mount. The system will be equipped with an on-axis jet viewing system as well as a perpendicular high resolution jet imaging system. Also supported will be time-resolved experiments employing either a nanosecond optical parametric oscillator (410-2200 nm). The pump laser beam will be delivered at ~60 degree from collinear to the x-ray beam with minimum lens distance of ~150mm. The incident photon energy is preferred to be 9.5 keV but justified deviations can be considered. The x-ray focus can vary over a range of ~2-3 µm to ~100 µm.

With this standard configuration, MFX will be able to support jet-based Serial Femtosecond Crystallography (SFX) experiments at atmospheric pressure and temperature with noise minimization from the Helium environment. This will be possible with or without a pump laser. Also supported will be Small Angle and Wide Angle X-ray Scattering (SAXS/WAXS) with or without a pump laser using the wide variety of sample delivery jets, either LCLS-owned or supplied by the user groups. The detector will be a Rayonix 170 capable of 10 Hz operation with 1920x1920 pixels.

Use of this Standard Configuration is contingent on acceptance by the users to use the following acknowledgment in any presentation or publication: "The HERA system for in helium experiments at MFX was developed by Bruce Doak and funded by the Max-Planck Institute for Medical Research."

See the detailed description of the MFX Standard Configuration #2.

To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. Please see the  table of required parameters of the MFX Standards Configuration #2.  No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the instrument staff.

 

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SXR Standard Configuration for Run 16

#1: The liquid jet end station in SXR

The LCLS facility owned liquid jet experimental end station, capable of investigating chemical dynamics in the liquid phase, will be offered as SXR’s Run 16 standard configuration. A newly commissioned, varied line-space plane grating spectrometer, optimized to operate from 250 eV to 2000 eV with an expected resolving power of 1500 to as high as 3000 at lower energies will be offered as well. The spectrometer can operate outside of the optimized energy range with compromised performance. The spectrum is detected with an in-vacuum CCD binned along the spectral energy direction to enable 120Hz readout. In this standard configuration the spectrometer is mounted perpendicular to the x-ray beam in the horizontal plane. The plane of the spectrometer optical elements will be vertical—parallel to the flow direction of the jet. For absorption spectroscopy, the LJE instrument will also have an in vacuum CCD mounted in a transmission geometry in SXR’s monitor tank assembly, located approximately 2 meters downstream of the X-ray interaction. The monitor tank will have two selectable filters for attenuation prior to detection. Thus, detailed investigations of valence electronic structure and the chemical state for chemically and biologically relevant molecular dynamics are possible both with resonant and non-resonant X-ray emission and absorption spectroscopies.

Time-resolved experiments employing tunable femtosecond pulses will be supported under this standard configuration. The fundamental and harmonics (800, 400 and 267 nm) of the SXR, ~50 fs Ti:Sapphire laser will be available, delivered to the sample collinearly with the x-rays. The configuration can also be used with a TOPAS-Prime Optical Parametric Amplifier (OPA) capable of 480-2400 nm output.

See the detailed description of the SXR Standard Configuration.

To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. The technical details of the standard configurations and the table of required parameters are available at the table of required parameters for Stanford Configuration #1. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should consult the website prior to proposal submission for the latest information. Address any questions to the SXR instrument staff.

 

#2: The RSXS end station in SXR

The Soft X-Materials hutch (SXR) will offer the RSXS end station to focus on time-resolved pump-probe resonant soft x-ray scattering and diffraction in the study of temporal dynamics in charge, spin, orbital, or lattice order in solid state materials. This end station is capable of achieving sample environment base pressures better than 10-8 Torr, and a sample loading/transfer system is installed for the rapid change of samples. In addition to the typical scattering angle in the horizontal plane (Θ), a motorized sample stage allows the sample to be rotated azimuthally about its surface normal (Φ) and to be pivoted in the vertical plane (χ). This sample stage is thermally contacted to a temperature control system, consisting of a liquid Helium cryostat and a heater, allowing the sample temperature to be changed from 15 K to 400 K. There are total six degrees of freedom for the sample: three translational (x, y, z from manipulator) and three rotational degrees of freedom (Θ,χ,Φ) with a differentially pumped rotary seal. The setup can be used with or without the ~100 fs SXR pump laser, which will deliver pulses of one wavelength per experiment from 800 nm, 1150-2400 nm or 4-17 microns. Pump pulses will be collinear with the x-rays.

This end station has two avalanche photodiodes and a multi-channel plate (MCP) detector. These detectors are mounted on a fully motorized in-vacuum detector stage, allowing detector manipulation in both horizontal (360 degrees) & vertical (90 degrees) scattering planes. Such capability can be used to efficiently search for super-lattice reflections over the full range of reciprocal space. X-ray absorption (XAS) measurements may also be performed by measuring total fluorescence yield.

A newly commissioned, varied line-space plane grating spectrometer, optimized to operate from 250 eV to 2000 eV with an expected resolving power of 1500 to as high as 3000 at lower energies will be offered as well, enabling FEL based RIXS studies. The spectrometer can operate outside of the optimized energy range with compromised performance. The spectrum is detected with an in-vacuum CCD binned along the spectral energy direction to enable 120Hz readout. In this standard configuration the spectrometer is mounted 135° to the x-ray beam in the horizontal plane.

See the detailed description of the SXR Standard Configuration #2.

To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. See the table of required parameters for Standard Configuration #2. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the instrument staff.   

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XCS Standard Configuration for Run 16

Time-resolved solution scattering/emission spectroscopy

The X-ray Correlation Spectroscopy instrument will be configured to study time-resolved solution scattering and/or emission spectroscopy. The incident photon energy will be fixed to 9.5 keV (deviations will be considered but not promised) and can be either monochromatic using the large offset double crystal monochromator using diamond 111 or with pink beam delivered by the XCS periscope. The setup will consist of a helium purged sample environment, a round or flat liquid jet and the sample recirculation system driven by HPLC pumps, a CSPAD-2.3M detector for wide angle x-ray scattering measurements and a von Hamos spectrometer with a CS140k detector for x-ray emission spectroscopy measurements. The spectrometer will be available for any of the following emission lines: Mn Kß1,3, Kß2,5 and Kα, Fe Kß1,3 and Kß2,5, Co Kß1,3 and Kß2,5, Ni Kß1,3 and Kß2,5, Ti Kß1,3 and Kß2,5 and V Kα. A femtosecond optical pump laser in collinear geometry with a wavelength in the range of 480-2400 nm will be available.
 
 
To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. Please see the table of required parameters for Standard Configuration. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the instrument staff.
 
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XPP Standard Configuration for Run 16

Kappa goniometer for time-resolved diffraction

The X-ray Pump Probe instrument will be configured for time-resolved x-ray diffraction. The setup will consist of a Kappa goniometer for sample manipulation with all 6 degrees of freedom, and a CS140k detector mounted on the detector robot arm for measurement of the diffracted x-rays over most of the upper reciprocal hemisphere. The incident photon energy will be fixed to 9.5 keV (deviations will be considered but not promised) using monochromatic beam delivered by the large offset double crystal monochromator using diamond 111. The Oxford nitrogen cryostream can be used to control the sample temperature down to 100 K. A femtosecond optical pump laser in collinear geometry with a wavelength in the range of 480-2400 nm will be available.

See the detailed description of the XPP Standard Configuration.

To be considered for scheduling in this standard configuration, users will be required to include a table in the proposal that lists the specific experimental parameters to ensure compatibility with these configurations. If the experimental parameters are not compatible with the standard configuration or if the table of parameters is incomplete, the proposal will be reviewed and considered for scheduling as general user proposal. Please see the table of required parameters for Standard Configuration. No fundamental changes to the standard configurations will occur, but some details of the configuration may be updated in response to inquiries, so users should recheck the website before submitting your proposal to confirm that you have the latest information. Address any questions to the instrument staff.

 

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